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[61 users on Ohloh]
wxPython is a Python extension module that wraps the wxWidgets cross-platform GUI library and provides an alternative to Tkinter and PythonWin. It attempts to mirror the class hierarchy of wxWidgets as closely as possible and is very versatile. It can be used to create standalone GUI applications or can be used in situations in which Python is embedded in a wxWidgets C++ application as an internal scripting or macro language. The currently supported GUIs are Win32, GTK/X-Windows, and Mac OS X.
[20 users on Ohloh]
qooxdoo is a comprehensive and innovative Ajax application framework. Leveraging object-oriented JavaScript allows developers to build impressive cross-browser applications. No HTML, CSS nor DOM knowledge is needed.

It includes a platform-independent development tool chain, a state-of-the-art GUI toolkit and an advanced client-server communication layer. It is Open Source under an LGPL/EPL dual license.

[4 users on Ohloh]
Eclox is a simple doxygen frontend plug-in for eclipse. It aims to provide a slim and sleek integration of the code documentation process into eclipse by providing a high-level graphical user interface over doxygen.
[1 users on Ohloh]
A very simple Python text editor.