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PageTree CMS
[1 users on Ohloh]
PageTree CMS is an lightweight multiplatform CMS that support Multithreading(Alpha), a Desktop interface (Alpha), that can work, with or without an database and supports templates of much other CMS'ses. Like: Joomla, Mambo, Wordpress, Drupal etc.

Source-Code Rewritten:
About a month ago we started rewriting the whole PageTree Core. Since then I really pushed at it to be released on New Years Eve! Since then a couple of security bugs came along, but most of them are fixed now....

[0 users on Ohloh]
Dabo is a 3-tier, cross-platform desktop application development framework, written in Python atop the wxPython GUI toolkit. And while Dabo is designed to create database-centric apps, that is not a requirement. Lots of people are using Dabo for the GUI tools to create apps that have no need to connect to a database at all.